School of Medicine - Basic Medical SciencePharmacology




The Department of Pharmacology was established in April, 1973, and in June, Professor Masahiro Yoshimura became the first Chair of the Department. In 1982, Professor Shiro Suzuki became the second Chair, and in 1994 Professor Matomo Nishio became the third Chair of the Department. The fourth Chair has been Professor Takaharu Ishibashi since 2016.
Our research interests include the following: (1) Studies of the mechanisms of vasodilatory agents such as glyceryltrinitrate; (2) Studies of the reception and conduction systems of pain and its regulatory mechanisms; (3) Studies of soluble guanylate cyclase redox states under pathological conditions ; (4) Studies of acetylcholine receptors in neuropsychiatric disorders. Through the use of pharmacological tools, we are aiming to elucidate the biological information transmission system and to find new molecular targets for drug therapy.
The pharmacological knowledge that medical students should learn is increasing year by year together with the growing number of new medicines and complicated usage for the increasing numbers of elderly patients and patients with comorbidity. Therefore, we select and teach important and essential knowledge to medical students, and try to develop the ability to choose optimal medication for each individual based on pharmacological knowledge, including side effects of the medication.

Contact Information

TEL: 076-218-8107 / FAX: 076-286-8191 / Email:


Professor and Chair

  • ISHIBASHI Takaharu 薬理-石橋教授2016(学報)

Associate Professor

  • MASUOKA Takayoshi

Senior Assistant Professer

  • TAWA Masashi

Research Fellow

  • NAKANO Katsuya

Research Achievements

Research Activities

  • Responsiveness of rat aorta and pulmonary artery to cGMP generators in the presence of thiol or heme oxidant. Masashi Tawa, Yuka Yamashita, Takayoshi Masuoka, Katsuya Nakano, Junko Yoshida, Matomo Nishio, Takaharu Ishibashi, J. Pharmacol. Sci., In press, 2019
  • Augmentation of endogenous acetylcholine uptake and cholinergic facilitation of hippocampal long-term potentiation by acetylcholinesterase inhibition. Takayoshi Masuoka, Junsuke Uwada, Makiko Kudo, Hatsumi Yoshiki, Yuka Yamashita, Takanobu Taniguchi, Matomo Nishio, Takaharu Ishibashi, Ikunobu Muramatsu. Neuroscience 404: 39-47, 2019
  • Responsiveness of internal thoracic arteries to nitroglycerin in patients with renal failure. Masashi Tawa, Takashi Kinoshita, Tohru Asai, Tomoaki Suzuki, Takaharu Ishibashi, Tomio Okamura. Heart Vessels., 33(6): 682-687, 2018
  • Regulation of synaptic acetylcholine concentrations by acetylcholine transport in rat striatal cholinergic transmission. Ikunobu Muramatsu, Junsuke Uwada, Takayoshi Masuoka, Hatsumi Yoshiki, Kiyonao Sada, Kung-Shing Lee, Matomo Nishio, Takaharu Ishibashi, Takanobu Taniguchi. J. Neurochem., 143(1): 76-86, 2017
  • Role of plasma S-nitrosothiols in regulation of blood pressure in anesthetized rabbits with special references to hypotensive effects of acetylcholine and nitrovasodilators. Takaharu Ishibashi, Tomoko Miwa, Naoki Nishizawa, Ikumi Shinkawa, Junko Yoshida, Tomie Kawada and Matomo Nishio. Biol. Pharm. Bull., 34 (8): 1307-1313, 2011

External Research Funding

  • Nakano K. Grant-in-Aid for Encouragement of Young Scientists (2019-2021, delegate, 19K18895) Abnormal Synaptic transmission in the medulla and the cervical cord in dry eye syndrome. ¥4,160,000
  • Tawa M. Grant-in-Aid for Encouragement of Young Scientists (B) (2017-2019, delegate, 17K15579) Coronary Stenosis and Soluble Guanylate Cyclase Heme Iron Redox State. ¥4,160,000
  • Yamashita Y. Grant-in-Aid for Encouragement of Young Scientists (B) (2017-2019, delegate, 17K16992) Investigation of dysfunction in corneal trigeminal nerve afferents in dry eye. ¥4,160,000
  • Masuoka T. Grant-in-Aid for Encouragement of Young Scientists (B) (2016-2018, delegate, 16K19023) The role of intracellular muscarinic M1 receptor in neuropsychiatric disorder. ¥4,030,000